A Huge Dose of Testosterone
Aman with advanced prostate cancer is believed to be cured after doctors ‘shocked’ his tumor to death with huge amounts of testosterone.
The result has been described as ‘unexpected’ and ‘exciting’ because most prostate cancer therapies work by depriving tumors of testosterone because cancer uses it as a fuel.
Other seriously ill men taking part in the same trial showed responses that astounded scientists, with tumors, shrinking and the progress of their disease, halted.
Levels of Prostate-Specific Antigen (PSA), a blood marker used to monitor prostate cancer, also fell in the majority of the 47 participants.
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One individual whose PSA levels dropped to zero after three months and show no remaining trace of the disease after 22 cycles of treatment appears to be cured, said the researchers.
Professor Sam Denmeade, from Johns Hopkins University School of Medicine in Baltimore, US, who led the study, said: “Our goal is to shock the cancer cells by exposing them rapidly to very high followed by very low levels of testosterone in the blood. The results are unexpected and exciting.
“We are still in the early stages of figuring out how this works and how to incorporate it into the treatment paradigm for prostate cancer.
“Many of the men have a stable disease that has not progressed for more than 12 months.
“I think we may have cured one man whose PSA dropped to zero after three months and has remained so now for 22 cycles. His disease has all disappeared.”
The facts | Prostate cancer
- 47,300 men in the UK are diagnosed with prostate cancer each year
- It is the most common cancer among UK men
- One in eight men will be diagnosed in their lifetime
- That likelihood is doubled for black men, with one in four being affected by the disease
- Men whose fathers or brothers have had prostate cancer are more than twice as likely to develop the disease
- 65–69 is the average age at which men are diagnosed
- 11,287 men in the UK die from prostate cancer each year – that equates to one every hour
- 330,000 men are living with or after the disease in the
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