Antidepressants Don’t Work as Advertised

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By Dr. Mercola

Depression and other mental health problems are at epidemic levels judging by the number of antidepressants prescribed each year.

According to CDC data,1 one in 20 Americans over the age of 12 report some form of depression, and 11 percent of the US population over the age of 12 is on antidepressant medication.2

This despite overwhelming evidence showing that antidepressants do not work as advertised.

At best, antidepressants are comparable to placebos. At worst they can cause devastating side effects, including deterioration into more serious mental illness, and suicidal or homicidal tendencies.

Virtually all of the school and mass shooters, for example, have been on antidepressants. Antidepressants are also prescribed to pregnant women, which can have serious repercussions for the child.

Research3 shows boys with autism are three times more likely to have been exposed to antidepressants known as selective serotonin reuptake inhibitors (SSRIs) in utero than non-autistic boys. Those whose mothers used SSRIs during the first trimester were found to be at greatest risk.

Recent research into the mechanisms driving anxiety and social phobias now turn conventional drug treatment with SSRIs on its ear.

Turns out these mental health problems are not due to low serotonin levels as previously thought. They’re linked to high levels! If these findings are taken as seriously as they should be, the mental health field is in for a major overhaul.

The Low Serotonin Theory Was Never Proven True, Yet Spawned a Booming Market of SSRIs

Prozac was released in 1987 in the US, giving rise to an entire new antidepressant therapy class known as selective serotonin reuptake inhibitors (SSRIs). Some of the most popular ones include:

  • Paxil (fluoxetine)
  • Celexa (citalopram)
  • Zoloft (sertraline)
  • Paxil (paroxetine)
  • Lexapro (escitalopram)

SSRIs work by preventing the reuptake (movement back into the nerve endings) of the neurotransmitter serotonin. This makes more serotonin available for use in your brain, which is thought to improve your mood.

Most people have heard of the “chemical imbalance” theory, which states that depression and anxiety disorders are due to low serotonin levels. Most believe this theory to be true. But the theory was just that—a theory. It soundsscientific, but there was actually no hard evidence behind it.

As explained by investigative health journalist Robert Whitaker, in 1983 the National Institutes of Mental Health (NIMH) investigated whether or not depressed individuals had low serotonin. At that time, they concluded there was no evidence that there is anything wrong in the serotonergic system of depressed patients.

Research 4, 5 published in 2009 added further evidence to the pile indicating the low serotonin idea was incorrect, as they found strong indications that depression actually begins further up in the chain of events in the brain. Essentially, the medications have been focusing on the effect, not the cause.

Drug companies kept running with the low serotonin theory though, as it justifies the aggressive use of antidepressants to correct this alleged “imbalance.” Now, Swedish research really throws the justification for using SSRIs to treat anxiety disorders into question.

Anxiety Linked to High Serotonin Levels, Making SSRIs a Questionable Remedy

More than 25 million Americans report suffering from social anxiety disorder, which makes them feel embarrassed or severely uncomfortable in public situations.

As with depression, low serotonin has been the prevailing theory for explaining social anxiety, and hence SSRIs are typically prescribed for this disorder. (Other commonly prescribed anti-anxiety drugs includebenzodiazepines, such as Ativan, Xanax, and Valium.

These are also associated with serious risks, including memory loss, hip fractures, and addiction. Among women who take SSRI’s to counter symptoms of menopause, the drugs can significantly elevate their risk of bone fractures, and this risk lingers for several years.

One recent study6 found that, compared to women treated with H2 antagonists or proton pump inhibitors (indigestion drugs), SSRI’s raised bone fracture rates by 76 percent in one year. After two years of treatment, the fracture rate was 73 percent higher.People who take these drugs are also nearly four times more likely to die prematurely than people who don’t, and also have a 35 percent greater risk of cancer.)

As reported by Medical Daily:7

[Dr. Tomas] Furmark and Dr. Mats Fredrikson, another professor of psychology at Uppsala University, questioned the underlying hypothesis of treating patients with SSRIs: What molecular role, exactly, does serotonin play in social phobia?8,9,10,11

To discover the truth, they used brain scanning technology, PET scans, to measure serotonin in the brains of volunteers with social phobia…

Communication within the brain works like this: Nerve cells release serotonin into the space between nerve cells. Then, serotonin attaches itself to receptor cells. Following this, serotonin is released from the receptor and returns to the original cell.

The researchers discovered patients with social phobia were producing too much serotonin in the amygdala. This brain region, tucked deep inside our skulls, is the seat of our most primitive emotions, including fear. The more serotonin produced in this area, then, the more anxious people feel in social situations.”

Previous studies have revealed that increased nerve activity in the amygdala is part of the underlying mechanism that produces anxiety. Basically, those with social phobia have an over-active fear center. These new findings provide additional information, suggesting increased serotonin production in the brain may be part of this mechanism.

Either way, when it comes to treating this anxiety disorder, increasing serotonin in your brain with an SSRI will not soothe your anxiety. It will increase it, making SSRIs a questionable treatment option.

Fermented Foods May Help Social Anxiety Disorder, Study Finds

The impact of your gut microbiome on your brain function has been confirmed by a number of studies, and research is moving rather swiftly in this area. One of the reasons for why the bacterial makeup of your gut would have an influence on your mental and emotional health relates to the fact that your gut actually works much like a second brain. Your central nervous system (composed of your brain and spinal cord) and your enteric nervous system (the intrinsic nervous system of your gastrointestinal tract) are created from identical tissue during fetal development. One part turns into your central nervous system while the other develops into your enteric nervous system. These two systems are connected via the vagus nerve, the tenth cranial nerve that runs from your brain stem down to your abdomen.

It is now well established that the vagus nerve is the primary route your gut bacteria use to transmit information to your brain. Even more interesting, serotonin is produced in your gut as well as your brain, by specific bacteria. In fact, the greatest concentration of serotonin is found in your intestines, not your brain.

It’s not so surprising then that researchers keep finding positive correlations between gut health and improved mental health. Most recently, researchers found that fermented foods and drinks helped curb social anxiety disorder in young adults. The study,12,13 published in Psychiatry Research, involved 710 psychology students at the College of William and Mary.

The participants filled out questionnaires rating their level of worry and anxiety, and documented their fermented food consumption over the past 30 days. Other factors such as healthy diet and exercise were also addressed. Among those who rated themselves as having a high degree of neurotic feelings, eating more fermented foods was linked to fewer symptoms of social anxiety. Meaning, the relationship between fermented foods and decreased social anxiety was strongest among those who tended to be more neurotic.

Key Factors to Overcoming Anxiety and/or Depression Without Drugs

It’s important to realize that your diet and general lifestyle are foundational factors that must be optimized if you want to resolve mental health problems such as depression or anxiety, because your body and mind are so closely interrelated. Compelling research demonstrates just how interconnected your mental health is with your gastrointestinal health for example. While many think of their brain as the organ in charge of their mental health, your gut may actually play a far more significant role. The drug treatments available today for depression are no better than they were 50 years ago.

Clearly, we need a new approach, and your diet is an obvious place to start. Research tells us that the composition of your gut flora not only affects your physical health, but also has a significant impact on your brain function and mental state, and your gut microbiome can be quickly impacted by dietary changes—for better or worse. Research has also revealed there are a number of other safe effective ways to address depression and anxiety that do not involve hazardous drugs. So, if you suffer from an anxiety- or depression-related disorder, please consider addressing the following diet and lifestyle factors before you resort to drugs:

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Tapping Your Anxiety Away

Energy psychology techniques, such as the Emotional Freedom Technique (EFT), can also be very effective for reducing anxiety by correcting the bioelectrical short-circuiting that causes your body’s reactions—without adverse effects. You can think of EFT as a tool for “reprogramming” your circuitry, and it works on both realand imagined stressors.

EFT is a form of psychological acupressure, based on the same energy meridians used in traditional acupuncture for more than 5,000 years to treat physical and emotional ailments, but without the invasiveness of needles. Following a 2012 review in the American Psychological Association’s journal Review of General Psychology, EFT is moving closer to meeting the criteria for an “evidence-based treatment.”

Recent research has shown that EFT significantly increases positive emotions, such as hope and enjoyment, and decreases negative emotional states, including anxiety. EFT is particularly powerful for treating stress and anxiety because it specifically targets your amygdala and hippocampus, which are the parts of your brain that help you decide whether or not something is a threat.18,19 If you recall NIMH’s explanation about how your amygdala and hippocampus are involved in anxiety disorders, you can see why tapping is such a powerful tool. EFT has also been shown to lower cortisol levels.20

Although you can learn the basics of EFT on your own, if you or your child has a serious anxiety disorder, I highly recommend that you consult a qualified EFT practitioner. For serious or complex issue you need a qualified health care professional that is trained in EFT21 to help guide you through the process, as it typically takes years of training to develop the skill to tap on and relieve deep-seated, significant issues.

There are situations where SSRIs may be warranted, but on the whole, these mind- and body-numbing drugs are grossly overused. I’d be willing to bet a majority of people taking them are not appropriate candidates, and would fare much better were they to address the basic, core issues relating to their general lifestyle and health. This includes proper diet, sleep, exercise, and employing effective tools for stress relief.

Exposure to the outdoors, such as walking barefoot through a grassy field and getting appropriate amounts of sun exposure, also should not be underestimated. If you’re suffering from emotional or physical pain, I encourage you to peruse my inventory of tens of thousands of articles, which address these issues and offer a multitude of safe and effective alternatives.

Sources and References

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